Background: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The type of breast cancer you have depends on where in the breast it started and other factors. 2 Several risk factors have been identified for breast cancer, including advancing age, genetics (eg, BReast CAncer 1/2 mutationsLearn about breast cancer signs and symptoms, mammograms, tests for gynecological cancers, and other cancers, including skin cancer, lung cancer, throat cancer, and bladder cancer. Manoe Konings, married to the cheeky singing doll Carla. Instead, signs and symptoms of inflammatory breast cancer include: Rapid change in the appearance of one breast, over the course of several weeks. BrandA relative survival rate compares women with the same type and stage of breast cancer to women in the overall population. 18. So Emotional. Yes. This video I recorded personally in Rostock at 31. Care for people diagnosed with cancer does not end when active treatment has finished. (The cells test "negative" on all 3 tests. A higher grade. Het zou leuk zijn om het live te zien. “Simply put, alcohol is toxic. Grade 2 or moderately differentiated (score 6, 7). Breast cancer can strike males and females, although women are about 100 times more likely to develop the disease than men. Manoe Konings Fanpage. Find the perfect manoe konings stock photo, image, vector, illustration or 360 image. C. Bangor, ME. Maurine Jasper ∙. Cancer Research UK: tests on breast cancer cells; Stage and grade of breast cancer Stage of breast cancer. It might sound strange, but cancer was the best thing that happened to me, I enjoy life so much more. IDC, also known as infiltrating. Advances in screening and treatment for breast cancer have improved survival rates dramatically. Possible signs and symptoms of breast cancer can include: a lump in the breast. In 2000/2001 Manoe Konings was diagnosed with breast cancer. Gnant M, Mlineritsch B, Schippinger W, et al. What does manoe konings father play with Andre rieu orchestra? eh, nothing? Guy is way too old to be in the JSO. Its incidence and death rates have increased over the last three decades due to the change in risk factor profiles, better cancer registration, and cancer detection. She is also a very courageous. M. Breast cancer is the second most common cancer diagnosed in. When breast cancer spreads to the lungs it may cause shortness of breath and a cough. That is, women with dense breasts have a higher risk of breast cancer than women with fatty breasts. Yes. Invasive ductal carcinoma. Breast tissue covers a larger area than just the breast, extending up to the collarbone and from the armpit to the breastbone. For breast cancer, this is even higher: 1 in 4 alcohol-attributable breast cancer cases in the Region is caused by this amount. " —Jane Cook. 31 март 2022 ·. For people with a very high risk of breast cancer, breast. Interviewer: Emil Szarkowics. PURPOSE Molecular biomarkers informing disease diagnosis, prognosis, and treatment decisions in patients with breast cancer are being uncovered by next-generation sequencing (NGS) technologies. Purpose. Pulling in of the nipple or pain in the nipple. In 2021, a total of 791 women died from this cancer, accounting for 12. (Map 1) About one in twenty females will be diagnosed with breast cancer over the course of their lifetime, although this number varies significantly by country. It may be difficult to detect (find) breast cancer early in pregnant or nursing women. Over 1. a rash. Breast cancer is cancer that starts in the breast tissue. . Study now. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. To address these symptoms, survivors need to have. Jenna Canzoniero is an oncologist specializing in breast cancer at the Johns Hopkins Kimmel Cancer Center. This video is about Manoe Konings. What does this mean in ENGLISH Ich schleiban austa be Clair es kumpent madre monstere aus-be aus-can-be flaugen begun be uske but bair?Overview. Metaplastic carcinoma (meh-tuh-PLAS-tik KAR-sih-NOH-muh) is a rare type of invasive breast cancer. Breast cancer is one of the most common cancers in women worldwide, accounting for approximately 570,000 deaths in 2015. Background: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. the skin on the breast is thicker or dimpled (it can look like an orange peel) a lump or swelling in one or both armpits. The ducts carry breast milk from the lobules, where it's made, to the nipple. Manoe Konings. Get information on breast cancer symptoms, awareness, survival rates, treatment, stages, & screening. You will now need to use the horizontal & verticle scroll bars to see Manoe up close & personal This is believed to be the largest, highest resolution photo of Manoe on the internet. Her and Carla worked with Andre Rieu and his JSO for about twenty years. Unavailable. 4% of all cancer deaths in females. There is a left and right breast and each one has mainly glands, ducts, and fatty tissue. Further-more, it has been shown that the Netherlands has a breast cancer related Disability Adjusted Life-Year (DALYs) burden of approximately of 1100 DALYs per 100,000 women [6]. Survival Rate for Women with Stage 2 Breast Cancer is Around 93% with Treatment. In trans women, the risk of breast cancer increased during a relatively short duration of hormone treatment and the characteristics of the breast cancer resembled a more feMale pattern. Johannes de Gorter proposed pus-filled inflammations as leading to cancer in the breast. Carla Bruni is his third wife. Her and Carla worked with Andre Rieu and his JSO for about twenty years. Most often, the higher the stage of the cancer, the. Breast cancer is the third leading cause of cancer deaths among females in Hong Kong, after lung and colorectal cancers. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer address all aspects of management for breast cancer. Blues Classical Country. The five-year-survival rate for stage 4 breast cancer is 29%. However, a focused white area with clear edges may be a cancerous or noncancerous tumor. Triple-negative breast cancer is an aggressive type of invasive breast cancer in which the cancer cells don’t have estrogen or progesterone receptors (ER or PR) and also don’t make any or too much of the protein called HER2. Patients. Setting: Specialised tertiary gender clinic in Amsterdam, the Netherlands. 21. rise precision forex course free download. She is a funny and talented musician. Difficult. Breast cancer is the most common nonskin cancer in women and accounts for 30% of all new cancers in the United States. For breast cancer that has spread to other organs, tumor markers that might be checked include carcinoembryonic antigen (CEA), cancer antigen 15-3 (CA 15-3), and cancer antigen 27-29 (CA 27-29). Breast cancer is currently one of the most prevalently diagnosed cancers and the 5th cause of cancer-related deaths with an estimated number of 2. Different people have different symptoms of breast cancer. ARIZONA Thank you Manoe, for contributing so much enjoyment to each & every DVD I watched & listened to, over & over & over. The stages of breast cancer. Breast cancer surgery may be used alone or in combination with other treatments, such as chemotherapy, hormone therapy, targeted therapy and radiation therapy. strong>Manoe Konings Fanpage. The crude death rate of breast cancer was 19. Played Chris Small in "La mare aux crocodiles" in 1992. Table 1. Purpose: In this study we aimed (1) to identify the most prevalent physical symptoms and functional limitations that limit physical activity of patients with palliative treatment for metastatic breast cancer (MBC) and (2) to identify their preferences for exercise-based physical therapy programs, as a first step towards the development of physical therapist. #18 Amazing Grace - Bagpipes - solo. Maastricht MECC Holland, July 11, 2010. Breast cancer (BC) is the most frequent cancer and the second cause of death by cancer in women worldwide. Hear Andre Rieu and two members of his Johann Strauss Orchestra, Frank Steijns and Manoe Konings, talk about the waltz and what it means. If a lump is present, it is not painful. Ductal carcinoma is the most common type of breast cancer. Advanced breast cancer with distant organ. 02 (95% confidence interval, 0. The few epidemiologic studies done thus far have not shown a relationship with cancer. Here she proudly played without her wig. Folate intake was associated with a lower risk for colon cancer: Konings et al. Stage 1B: T1N1miM0. There's a good chance of recovery if it's detected at an early stage. Apr 28, 2012 - Explore Pauline Till's board "Manoe Konings" on Pinterest. The best tech tutorials and in-depth reviews; Try a single issue or save on a subscription; Issues delivered straight to your door or device; free black porn full length movies. Sanné Mestrom:. Mammogram. Thickening or swelling of part of the breast. Nov 27, 2020 - Manoe Konings Andre Rieu, Johann Strauss Orchestra, JSO, information, biography, news, background and history. Congratulation to Manoe for being able to keep up with Heidi (I'm now ducking & running for cover under a large rock) #24 Marina - Whistle blower & gord shaker. A person’s risk of developing breast cancer increases as they get older. Manoe, Debbie and Matt in 1979. Manoe was diagnosed with cancer, fought that disease and won. Manoe Konings Death Fact Check. She fought in 2001 and did not give up. Breast cancer incidence increases with age and peaks among persons ages 70 to 74 years, though rates in persons age 75 years or older remain high (460. Marit Busund, Giske Ursin, Eiliv Lund, Tom Wilsgaard and Charlotta Rylander. This type of cancer forms in the lining of a milk duct within your breast. The chance of getting cancer increases as you get older. View 12 more commentsManoe Konings Death Fact Check. In 2001 she, André and the JSO appeared in the José Carreras Gala for cancer relief. Assuming that the breast cancer mortality rate is decreased by 2. Nagyon szinpatikus , emberi, humoros , szeretettel teljes emberekkel dolgozik Művészúr! Gratulálok . With Dorona Alberti, Gary Bennett, Thomas Greuel, Manoe Konings. Manoe Konings Death - Manoe Konings Cause Of Death: On January 2, 2022, Manoe Konings died abruptly. With this tragic sentiment, we send our sympathies to Manoe Konings. 88. In the later stages of breast cancer, the tumors have spread to other lymph nodes. The acrylamide risk estimates were adjusted for possible brain cancer risk factors. a change in the shape or size of the breast. A breast tumor is larger than 50 millimeters, and the cancer has spread to between one and three nearby lymph nodes. In 2000/2001 Manoe Konings was diagnosed with breast cancer. The journal provides the best of up-to-date information on breast cancer, presenting readers. But when it does, symptoms may include: A change in the size, shape or contour of your breast. a change in the shape or appearance of the nipple, such as crusting, sores, redness or inversion (where the nipple turns in instead of pointing out) changes to the skin of. Cancer is a life-threatening disease, its treatment is demanding and burdensome, it is associated with powerful emotions, and approximately one-third of patients fulfill the criteria of a mental disorder or experience distress . Puccini, where Carla is accompanied by the mandolin ensemble and Manoe Konings on clarinet. She was able to read our comments and even replied: “I have an ugly, so called mixed cancer tumor. Gooren, M. Source: Division of Cancer Prevention and Control, Centers for Disease Control and Prevention. 2 /26. Inflammatory breast cancer is the appearance of inflamed breasts (red and warm) with dimples and/or thick ridges caused by cancer cells blocking lymph vessels or channels in the skin over the breast. Nipple changes Enlarge image. Click on the link below to listen to the interview and Manoe's music selection: 1. La Bohème, Act II: "Aria: Quando M'en Vo". " With metastatic breast cancer, common concerns include discussions, anticipatory grief,. Signs and symptoms of local recurrence on the chest wall after a mastectomy may include: One or more painless nodules on or under the skin of your chest wall. Being part of this group requires mutual trust. The following are a few milestones worth noting: 1882: William Halsted performs the first radical mastectomy to treat breast cancer. The current approach to the management of emotions in patients with cancer is “distress screening and referral for the provision of psychosocial care. The World Health Organization (WHO) released a new Global Breast Cancer Initiative Framework today providing a roadmap to attain the targets to save 2. We learnt with a sad heart and deep grief that the trend concerning Manoe Koning's death is still continuing on. Unusual warmth of the affected breast. Manoe Konings dating history, 2023, 2022, list of Manoe Konings relationships. 2018. There is a left and right breast and each one has mainly glands, ducts, and fatty tissue. Participants: 2260 adult trans women (male sex assigned. dimpled, orange-peel-looking skin. Pembrolizumab for Triple-Negative Breast Cancer. The last paragraph says that it is unclear weather Carla will be able to join her partner. Very easy. Played Prosecutor in "The Native Who Caused All the Trouble" in 1989. See more ideas about andre rieu, andre, andré léon marie nicolas rieu. Purchase Options. On October 8, 2021 Beate Gündler notified on Facebook that her days were numbered as she was saying farewell to all the André fans around the world. However some people live with this chronic illness for many years. Breast Cancer Research 2023 25 :130. A lump or thickening in or near your breast or in your underarm that persists through your menstrual cycle. Abstract. inverted (turned in) nipples. 5 million more patients will stay alive from 2020 to 2040 [95,96]. R. a nipple turning in (inverted nipple)Too often, these preparations are not done and people end up going to the hospital against their wishes. Playing the guitar, besides singing, keeps her in balance. Explore Manoe Konings's discography including top tracks, albums, and reviews. 2% and 35. The increase was driven by DCIS and early breast cancer as the incidence of locally advanced and metastatic breast cancer remained stable. Never has been in the JSO either. The safest and most inclusive global community of photography enthusiasts. Stage IV (metastatic) breast cancer is treatable but not curable. She is also a very courageous young woman. ARIZONA by Bill Cole 1 7Breast Cancer, Version 3. sex or gender. Jazz Latin All Genres. Despite her illness and treatment, she remained playing with the JSO and only missed a single tour to the USA. . 204 Thus, the significance of BRCA1 and BRCA2 in breast. Makes you proud to be Scottish even if. Stage 1: At this stage, the tumor measures up to 2 centimeters (cm) across. See answer (1) Is carla maffioletti still married to manoe konings? According to a Dutch article about Manoe and her dad being members of a brass band for 40 years, they are. Manoe Konings was reading music before she knew her A B C’s. Share your videos with friends, family, and the worldDietary choices may make a difference. Grade 3 is a faster-growing cancer. The few epidemiologic studies done thus far have not shown a relationship with cancer. A study found that breast cancer deaths among women in the United States dropped 1% per year from 2014 to 2018. But when it does, symptoms may include: A change in the size, shape or contour of your breast. These appearances don’t necessarily mean you have breast cancer since most breast lumps are not. Jul 25, 2013 - Andre Rieu (Holland) his orchestra, choir and Manoe Konings (Holland) plays Hava Nagila on the clarinet. She is also a very courageous young woman. Both breast and cervical cancer have been identified as a national priority with increasing incidences occurring. Breast cancer surgery is a key component of breast cancer treatment that involves removing the cancer with an operation. Language: Dutch. Breast cancer symptoms. . Aug 21, 2020 - Manoe Konings Andre Rieu, Johann Strauss Orchestra, JSO, information, biography, news, background and history. Who is manoe konings husband? nobody is, she has a wife, not a husband. Click on the link below to listen to the interview and Manoe's music selection: 1. She created a CD with the ensemble. a great sense of humor. Manoe Konings - Biography. She is also a very courageous young woman. Manoe at her best having fun on stage. Watch. A change to the skin, such as puckering or dimpling. , about 245,000 cases of breast cancer are diagnosed in women and about 2,200 in men. What are the symptoms of breast cancer? Signs and symptoms of breast cancer include: A lump or swelling in the breast, upper chest or armpit. 1. HRs were not significantly increased either when. The type and stage. Purpose: The number of qualitative studies exploring cancer survivor experiences has significantly increased in recent years, with a large number of systematic reviews now published. Breast cancer is the most common malignancy in females,1 but it is rare in males. Respect everyone's privacy. When breast cancer is diagnosed, your doctors will give it a stage. Breast cancer deaths are decreasing in the United States overall, but disparities still exist. There is a lack of comparative data to help clinicians decide if CDK4. Each year, about 55,000 women are diagnosed with breast cancer in the UK. Les Filles De Cadiz. This process is called staging. S. Male and female adults:. Overall, the rate of breast cancer declined by about 40% between 1989 and 2017. cancer in the United States. 5 percent per year, it is anticipated that 2. Breast cancer often has no symptoms, but you may notice something you want the doctor to check. Apr 28, 2012 - Explore Pauline Till's board "Manoe Konings" on Pinterest. Women aged 50 to 74 years. ∙ 3y ago. The overall incidence of breast cancer increased from 103. For women with stage IV breast cancer, systemic drug therapies are the main treatments. Some women are at greater risk of breast cancer. Andre Rieu Glasgow SSE Hydro 2015 Manoe Konings, Sanne Mestrom, Nadejda Diakoff by Andrew 1 View all All Photos Tagged Manoe Konings. If breast cancer spreads to another part of the body, it is called secondary breast cancer. Stage 4 is a metastatic cancer. About 55,720 new cases of ductal carcinoma in situ (DCIS) will be diagnosed. Approximately 10%–20% breast cancer patients have at least one first-degree relatives affected with breast cancer. 4K monthly listeners. Ductal carcinoma in situ (DCIS) is a breast disease that may lead to invasive breast cancer. Breast cancer cells sometimes make substances called tumor markers that can be found in the blood. . If you have breast cancer, you should be assigned a multidisciplinary team (MDT), which is a group of specialists who work together to provide the best treatment and care. A lump or thickening in or near your breast or in your underarm that persists through your menstrual cycle. Treatment can often shrink tumors (or slow their growth), improve symptoms, and help some women live longer. What does manoe konings father play with Andre rieu orchestra? eh, nothing? Guy is way too old to be in the JSO. Nipple or breast skin that’s dry, flaking, thickened or red. Between 1990 and 2014, ten-year overall survival rates increased from 87% to 93% for. Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. We are very sad and our thoughts and prayers are with Jenny and their family. Carla Bruni is his third wife. A newly inverted nipple. peeling or flakey skin. Australia at Rod Laver Arena on 29 Oct 2009 Manoe playing the bagpipes, just one of the many, many musical instruments she plays I believe this is the largest, high resolution photo of Manoe on the internet. Elizabeth Drury. Some cancer types were found in both rats and humans, e. Comments. Despite her illness and treatment, she remained playing with the JSO and only missed a single tour to the USA. edit. Multidisciplinary Approach for Management of Early Breast. Whether the cancer is only in the breast, is found in lymph nodes under your arm, or has spread outside the breast determines your stage of breast cancer. March 31, 2022 ·. brain cancer seizures life expectancy. S. With Johann Strauss Orchestra since: 1989-Role in orchestra: plays clarinet, saxophone, bagpipes, guitar (and is a comedian) She jokes all the time, including during this interview. Being a long-term survivor is usually defined as living five or more years beyond a diagnosis of stage 4 breast cancer. Breast cancer is the most common cancer in women, with an incidence that rises dramatically with age. Despite her illness and treatment, she remained playing with the JSO and only missed a single tour to the USA. In Memoriam (6) 2021. The stages of breast cancer range from 0 to IV (0 to 4). [ 122,144 ]. Mumtoz musiqa. Endocrine therapy plus zoledronic acid in premenopausal. Persistent disparities in the burden of breast cancer between African Americans and White Americans have been documented over many decades. 1% of deaths occurred in transitioning countries, by 2040 this share will rise to 22. A person’s risk of developing breast cancer increases as they get older. 2. A 2019 study. Here she proudly played without. . 18 3. Swelling in all or part of a breast. ∙ 3y ago. The American Cancer Society's estimates for breast cancer in the United States for 2023 are: About 297,790 new cases of invasive breast cancer will be diagnosed in women. Change in the size, shape or appearance of a breast. The most common and widely accepted classification of breast cancer is from an immunohistochemical perspective, based on the expression of the following hormone. For official information go to Andre's website. According to a Dutch article about Manoe and her dad being members of a brass band for 40 years, they are. Apart from non-melanoma skin cancer, breast cancer is the most common cancer in women of all races, with a lifetime risk of 1 in 27 in South Africa, according to the 2019 National Cancer Registry (NCR). Interviewer: Emil Szarkowics. breast cancer, disease characterized by the growth of malignant cells in the mammary glands. 5 cases per 100,000 women ages 75–79 and 80–84 years, respectively, compared with 477. Women with breast. 26 years ago. Triple-negative breast cancer, also called basal-like breast cancer, is not sensitive to. José Carreras Gala, 2001. “Breast cancer occurs in 1 in 7 women whereas. Abstract. On October 8, 2021 Beate Gündler notified on Facebook that her days were numbered as she was saying farewell to all the André fans around the world. Metaplastic carcinoma (meh-tuh-PLAS-tik KAR-sih-NOH-muh) is a rare type of invasive breast cancer. The earliest form (in situ) is not life-threatening. Manoe Konings Death - Manoe Konings Cause Of Death: On January 2, 2022, Manoe Konings died abruptly. 2 and 416. Given the level of alcohol consumption in the U. country of citizenship. At Memorial Sloan Kettering Cancer Center (MSK), we have specialists who regularly care for men with breast cancer. Jul 01, 2020 · Manoe was born on March 10th 1961 in Maastricht, in a musical family. Metastatic breast cancer has a less favorable prognosis. Manoe Konings, Clarinet Arthur Cordewener, Oboe Ruud Merx, T rombone and Lin Jong, Violin. Cancer is a disease in which cells in the body grow out of control. "Breast cancer changes you, and the change can be beautiful. It is about Manoe Konings as she plays the song Highland Cathedral with the bagpipes. Despite her illness and treatment, she remained playing with the JSO and only missed a single tour to the USA. William J Gradishar 1 , Meena S Moran 2 , Jame Abraham 3 , Rebecca Aft 4 , Doreen Agnese 5 , Kimberly H Allison 6 , Bethany Anderson 7 , Harold J Burstein 8 , Helen Chew 9 , Chau Dang 10 , Anthony D Elias 11 , Sharon H Giordano 12 , Matthew P Goetz 13 , Lori J. Manoe, Debbie and Matt in 1979. We learnt with a sad heart and deep grief that the trend concerning Manoe Koning's death is still continuing on throughout all social media platforms. Manoe Konings (Clarinet, Clog Dancer, Saxaphone, Guitar, Ice Skater, Bagpipes, Whistle, Gord Shaker) 23 Jun 2009; Phoenix. Learn more about living as a breast cancer survivor and get information about next steps, follow up care, and ways to look after your health. What a magnificent performance by all and what a special talented lady, Manoe. Manoe is alive and kicking. Rochelle G. But her will to survive and to continue making music together with all of us gave her the courage and strength to overcome this illness. Nipple discharge. Playing the guitar, besides singing, keeps her in balance. Carla Maffioletti, Mandoline Ensemble the Strings & Manoe Konings. In 2000/2001 Manoe Konings was diagnosed with breast cancer. Web about 16 years ago our clarinettist manoe koning became very ill, she had breast cancer. When did Manoe Konings get breast cancer? José Carreras Gala, 2001. Living 10 or more years isn't unheard of, and the 10-year survival rate for primary or de novo metastatic breast cancer is around 13%. popular; trending; lists; login; Manoe Konings Manoe Konings Saxophone. Abstract. When did Manoe Konings get breast cancer? José Carreras Gala, 2001. Breast cancer can be invasive or non-invasive (in-situ). Black women are more likely to have an aggressive form of breast cancer. Breast cancer is a disease in which abnormal breast cells grow out of control and form tumours. The treatment you need depends on the type of breast cancer you have as well as your general health. Is carla maffioletti still married to manoe konings? According to a Dutch article about Manoe and her dad being members of a brass band for 40 years, they are. . The number of qualitative studies exploring cancer survivor experiences has significantly increased in. The ducts carry breast milk. Most women with breast cancer have some type of surgery. The few epidemiologic studies done thus far have not shown a relationship with cancer. In America, it is estimated that 30% of all new cancer cases (252,710). Aug 21, 2020 - Manoe Konings Andre Rieu, Johann Strauss Orchestra, JSO, information, biography, news, background and history. 03:31. —Andrew Jackson (1767–1845) “ I esteem it the happiness of this country that its. . Start here to find information on breast cancer treatment, causes and prevention, screening. 1 From 2001 to 2016, more than 2. The overall incidence of breast cancer increased from 103. Mammograms can detect breast cancer early, possibly before it has spread. (This rate is based on de novo cases, or cases in which stage 4 was the initial diagnosis. Playing via Spotify. Article. In 2001 she was very ill, but as soon as she was able to make music again she was back on stage playing her music. It also makes up about 80 percent of all invasive breast cancer diagnoses. Het zou leuk zijn om het live te zien. These results suggest that breast cancer screening guidelines for cisgender people are sufficient for transgender people using hormone treatment. S. Manoe Konings plays clarinet, saxophone and guitar, but also bagpipe. It features editorials, review articles, original articles, case reports, and short papers. This video h. A mammogram is an X-ray of the breast. Anyone can find this group. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer. The cells are slower-growing, and look more like normal breast cells. Most cancers in female breasts form shortly before, during, or after menopause, with three-quarters of all cases being. Protein-truncating variants in 5 genes ( ATM, BRCA1, BRCA2. “My family is deeply saddened to inform you that my handsome good old Charlie passed away in his sleep yesterday, April 20 2017.