Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Modvigil is the greatest product on the market if you want to try Modafinil. Although it was specifically designed for treating excessive daytime sleepiness, it is more popularly used off-label to promote focus, boost memory, and ultimately increase productivity. Modafinil is a prescription drug that promotes wakefulness. Modafinil is a medication that promotes wakefulness. It works by exciting your nervous system to release chemicals that make you feel more energetic. Achieving decompression without CSF over-drainage remains a challenge in hydrocephalus. An implantable device intended to function as part of a lumboperitoneal, ventriculoperitoneal or ventriculoatrial shunt to regulate the pressure and flow level of cerebrospinal fluid (CSF) from the lumbar spine or brain to the peritoneum/heart right. It is sometimes used off-label to treat symptoms of ADHD in adults 18 years of age and older. Top choices include Adderall (amphetamine) and Ritalin (methylphenidate) — treatments for attention-deficit hyperactivity disorder (ADHD) — and modafinil, which is a medication for sleep. Progavi Oral Suspension (500 mg+213 mg+325 mg)/10 ml is also used to associated treatment for these conditions: Acid Reflux, Acid indigestion, Bloating,. Purpose Achieving decompression without CSF over-drainage remains a challenge in hydrocephalus. The medicines were amantadine, methylphenidate, and modafinil. per day , which is lower than (±)-modafinil (200–600 mg, p. গ্রা. 0 mmHg ml-1 min-1. Hb (Hemoglobin) Complete Hemogram (CBC & ESR) Progivian 400mg Tablet is used in the treatment of Hormone replacement therapy,Female infertility. Achieving decompression without CSF over-drainage remains a challenge in hydrocephalus. flushing or redness of the skin. Other side effects of Provigil. 7), translating to 8. Notably, modafinil has fewer side effects and is better tolerated than traditional stimulant drugs such as Adderall and Vyvanse. shift work sleep disorder. m. Avoid or Use Alternate Drug. PROVIGIL® (modafinil) tablets, for oral use, C-IV Initial U. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. No difference was found between modafinil and placebo. Avoid or Use Alternate Drug. The Food and Drugs Administration (FDA) has approved two wakefulness-promoting agents for treating shift work disorder, modafinil Trusted Source U. ) is a product of Beximco Pharmaceuticals Ltd. 8 mg/L after 6 hours. Progavi Syrup-200 mlHow Progavi Oral Suspension (500 mg+213 mg+325 mg)/10 ml works. Either the side effects were intolerable, or the medicine just didn't work. Sunosi is a once-daily medication that may be used to increase wakefulness in people with narcolepsy or obstructive sleep apnea (OSA). To make sure armodafinil is safe for you, tell your doctor if you have ever had: liver or kidney disease; a heart muscle or valve disorder such as mitral valve prolapse; high blood pressure, heart disease, or prior heart. It’s FDA approved to treat symptoms in adults over. Adjusted for baseline scores. 0 WITH BURRHOLE RESERVOIR. This medicine is a. 99 for the most common version, by using a GoodRx coupon. Alertec: Modafinil belongs to the group of medicines known as central nervous system (CNS) stimulants. Introduction. Nuvigil is a very similar drug to Provigil. The team compared these medicines with a placebo. It is sparingly to slightly soluble in ethanol and acetone. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs. NDA 20-717 PROVIGIL® (modafinil) Tablets FDA Approved Labeling dated August 17, 2007 enantiomers do not interconvert. This should be taken into account when a highly restricted salt diet is recommended, e. Modafinil is not an amphetamine, but it is a therapy approved for people who do shift-work. You need to not breast-feed while using this medication. This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue ≥3 months after stroke. Modafinil is a wakefulness-promoting agent approved for the treatment of narcolepsy. As a stimulant, it is not as powerful as amphetamine, but it does produce similar effects to the more potent. Among them, 841 (3. 0 is a shunt system that regulates the cerebrospinal fluid pressure in patients with hydrocephalus. 03 ₹ 649. Provigil is a prescription medication approved by the U. The American Academy of Sleep Medicine (AASM) and the European Federation of Neurological Societies recommend modafinil as the first treatment option. mental/mood changes (such as agitation, confusion, depression, hallucinations, rare thoughts of suicide). The most popular generic modafinil brands are Modalert, Waklert, Artvigil, and Modvigil. However. Get emergency help immediately if any of the following symptoms of overdose occur while taking modafinil: Methods. Caffeine. The Miethke M. Prescribed for Shift Work Sleep Disorder, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome. Get modafinil for as low as $21. ) is a product of Beximco Pharmaceuticals Ltd. 19 ₹ 3,899. I view this medication as a true miracle in my life. 16. BACKGROUND: Overdrainage is a common complication associated with shunt insertion in normal-pressure hydrocephalus (NPH) patients. Keep in mind that modafinil or armodafinil may not completely treat your symptoms. গ্রা. To make sure armodafinil is safe for you, tell your doctor if you have ever had: liver or kidney disease; a heart muscle or valve disorder such as mitral valve prolapse; high blood pressure, heart disease, or prior heart attack; Modafinil is a medication prescribed to treat excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. 0 programmable valve in a paediatric population. trembling or shaking. PRECHAMBER. The ProGav Miethke shunt is composed of an adjustable ballon-spring valve unit and an integrated over-drainage compensating gravitational device (known as the shunt assistant). This is a decision you and your doctor will make. Provigil (brand name for modafinil) is a prescription drug that’s used to treat sleep disorders such as narcolepsy, shift work sleep. Trouble with breathing. Modafinil. Provigil has helped quite a bit but does have some cons. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Umhau was a senior clinical investigator at the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH). A placebo is a pill with no active ingredients. Across all years, 89% of patients prescribed modafinil did not have an on-label diagnosis, and patients with. 2273 100 Years of Cleveland ClinicThis medicine is available only with your doctor's prescription. Adderall is a stimulant medication that contains two active drugs: amphetamine and dextroamphetamine. Some drugs used to treat depression, including selective serotonin reuptake inhibitors, may be recommended. It decreases excessive sleepiness caused by narcolepsy and other sleep disorders, obstructive sleep apnea. Compared with other drugs of this class, Provigil has less of an effect on memory and alertness. Side effects are uncommon but may include headache, nausea or anxiety. Differential pressure valves are a popular treatment modality, with evidence suggesting that incorporation of gravitational units helps minimise over-drainage. Before taking this medicine. g. Keep from freezing. SUNOSI (solriamfetol) is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (OSA). But it has 90% less salt than the older drug. blue® valve in patients with iNPH. Differential pressure valves are a popular treatment modality, with evidence suggesting that incorporation of gravitational units helps minimise over-drainage. dryness of the mouth. They concluded that the drug. We hypothesise that the use of a fixed pressure gravitational valve for all de novo shunt insertions decreases the rate of functional revisions and that by implementing the routine use of gravitational. It consists of an adjustable differential pressure unit and a gravitational unit, such as the SA 2. Alleviates the painful conditions resulting from gastric acid & bile reflux into oesophagus. AccessGUDID - proGAV 2. Avoid or Use Alternate Drug. Figure 1. Modafinil (Provigil) is a prescription medication used to improve wakefulness in people who have extreme sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. As a Schedule IV controlled substance, Provigil is illegal to use without prescription. Provigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. Provigil is a medication prescribed to promote wakefulness in those who find it difficult to stay awake. Provigil has been the only medication out of the tons I have been previously prescribed that finally worked in helping me stay awake. The proGAV 2. The response of ICP to valve setting adjustments was classified as ‘expected’ in 54 cases (57%), ‘paradoxical’ in 17 cases (18%) and ‘no effect’ (Δ night ICP < 1 mmHg) in 23 cases (24%). Prescribed for Shift Work Sleep Disorder, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome. PROVIGIL prescription and dosage sizes information for physicians and healthcare professionals. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. ’ 1 1 Allin DM, Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD. For the full list of excipients, see Section 6. It may be covered by your Medicare or insurance plan, but some pharmacy coupons or cash. Keep all medicine out of the reach of children. Modafinil is a medication used to treat narcolepsy and other sleep disorders. 223. Similarly, Adderall improves attention and focus while decreasing impulsivity and aggression, bringing the brain to. shortness of breath. Modafinil improves memory, and enhances one's mood, alertness and cognitive powers. গ্রা. গ্রা. )/১০ মি. Modafinil may also be used for purposes not listed in this medication guide. The goal of the study is to verify theoretical benefit of ventriculoperitoneal shunting with MIETHKE M. Provigil () is a member of the CNS stimulants drug class and is commonly used for Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, and Shift Work Sleep Disorder. Modalert 100 Tablet is used in the treatment of Narcolepsy (Uncontrollable daytime sleepiness). sleep problems (insomnia). diarrhea. Nuvigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder. Nuvigil is used in adults to treat: narcolepsy. proGAV MRI SAFETY INFORMATION MR Conditional Non-clinical testing has demonstrated that the proGAV is MR Conditional. Axitinib. ; Hepatic Impairment: No dose modification necessary. Taking a medication with certain vaccines, foods, and other things can affect how the medication works. per day), and may translate into an improved side-effect profile. Usual Adult Dose for Narcolepsy. OTC Medicine Home Prescription Medicines Prescription Medicines. 63%) have memory loss. Methods. Anti-siphon devices. Modafinil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep. Progavi Suspension (500 mg+213 mg+325 mg)/10 ml (প্রোগ্যাভি (৫০০ মি. It works by promoting wakefulness. trouble in urinating. This article reviews the. Fastest-Acting Modafinil Alternative: Lucy Nicotine. লি. Adzenys ER, Adzenys XR-ODT, and Dyanavel XR The integration of gravitational valves in VPS was established to counteract the hydrostatic draining force and to approach a physiological condition of the cerebrospinal diverting system. Its generic name is Sodium Alginate + Sodium Bicarbonate + Calcium Carbonate. Although the VPS extends survival. John C. Dosage in Narcolepsy and Obstructive Sleep Apnea (OSA) The recommended dosage of PROVIGIL for patients with narcolepsy or OSA is 200 mg taken orally once a day as a single dose in the morning. S. It is available on prescription for a number of sleep disorders, such as narcolepsy. +২১৩ মি. o. Provigil is a medication that is frequently recommended for treating sleep disorders and excessive daytime sleepiness. Using adjustable. Who we are. It was first developed in the 1970s, but it wasn't approved for use in the United States until 1998. This study seeks to describe the utility of the proGAV®2. upset stomach, dry mouth, anxiety, nervousness, dizziness, and. Different individuals may respond to medication in different ways. Sunosi. Progavi Suspension (500 mg+213 mg+325 mg)/10 ml (প্রোগ্যাভি (৫০০ মি. In vitro. Before taking this medicine. S. Examples include heart-related side effects, such. The proGAV®2. The exact mechanism of action is unclear. +৩২৫ মি. “Evidence that nicotine can produce beneficial effects on some cognitive functions has become firmer and there can now be little doubt that some such effects do occur…”. Common nootropics include modafinil, methylphenidate (Ritalin), and piracetam. For over 20 years Dr. Modafinil is a white to off-white, crystalline powder that is practically insoluble in water and cyclohexane. o. (An active ingredient is what makes a drug work. You should not use Nuvigil if you have ever had a rash or allergic reaction caused by armodafinil or modafinil (Provigil). Modafinil, available under the brand name Provigil, is a central nervous system stimulant drug. Provigil (modafinil) indications, usage, warnings, adverse reactions, and more. The programmable valve is an important advancement in shunt technology. Its mechanism of action is complex with evidence of effects across a wide range of neurotransmitter systems, including catecholamines, serotonin, glutamate, GABA, and orexin. Provigil is a brand name version of modafinil. ; Children under 6 years: Not recommended. 29 with our coupon. This means that the opening pressure varies depending on the body position of the patient. When prescribed for cocaine or crystal meth addiction, Modafinil acts as a medication-assisted therapy (MAT). 1 List of Excipients. Modafinil does not cure these conditions and will only work as long as you continue to take it. Modafinil: Side Effects, Drug Interactions, and Mechanisms of Action. It is essential to discuss with a clinical care expert before adjusting daily dose and treatment. 0 Valve is a position-dependent valve, meaning the opening pressure changes gradually corresponding to the patient's body position. This one may be shocking. It consists of a ball-cone valve with an adjustable opening pressure, and a fixed pressure gravitational unit. The generic version of Provigil is modafinil. Two clinical trials compared different doses (200 mg and 400 mg) of modafinil with placebo. It’s a prescription drug used to relieve excessive sleepiness in adults. Achieving decompression without CSF over-drainage remains a challenge in hydrocephalus. There are Modafinil over-the-counter and natural alternatives that are deemed effective, and these are listed below. It is safe and effective, but you should always take the entire prescribed amount to benefit fully from the therapy and to avoid a relapse of infection. Stimulant medication, such as modafinil (Provigil, Alertec), might be prescribed to help you stay awake during the day. The "virtual off" function provided a. Provigil - 100 mg, 30 tablets starting at only $19. 28, 95% CI 0. The American Academy of Sleep Medicine (AASM), in a practice parameter and review of medical therapies for OSA, [153, 218] listed the use of protriptyline as a guideline (patient care strategy based on level 2 or 3 evidence). The cost for Provigil oral tablet 100 mg is around $1,503 for a supply of 30 tablets, depending on the pharmacy. See moreGeneric Name: modafinil Modafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep ( obstructive. Conclusions. Although Provigil effectively treats sleep deprivations, it has numerous side effects, including severe skin reactions that require urgent medical care. 002, I 2 =14%) but not in patients with MS or TBI. Includes dosages for Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome and Shift Work Sleep Disorder; plus renal, liver and dialysis adjustments. Background Idiopathic normal-pressure hydrocephalus (iNPH) is a distinct form of dementia, characterized by gait ataxia, cognitive impairment and urinary incontinence. Progavi Suspension (500 mg+213 mg+325 mg)/10 ml (প্রোগ্যাভি (৫০০ মি. 2 out of 10 from a total of 13 reviews for the treatment of Shift Work Sleep Disorder. 126 reviews submitted with a 7. Adults between the ages of 18 and 60 years were eligible if they worked each month at least five night shifts for 12 hours or less, with 6 hours or more worked between 10 p. It also stimulates mood, thinking, and feelings. Then the valve can be located on the patient‘s head with the forefinger. Study drugs. Medication to increase walking speed. g. Use this coupon to get this price at any SAMS PHARMACY location. Also, the brain needs lots of rest for its normal functions, and because of the lack of adequate rest, Provigil induces a. Modafinil, sold under the brand name Provigil, is a medication used primarily to treat sleep disorders like narcolepsy and sleep apnea. PROVIGIL is indicated to improve wakefulness in adult patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD). This medicine is available only with your doctor's prescription. This study seeks to describe the utility of the proGAV®2. This study seeks to describe the utility of the proGAV®2. In some countries, the drug is available over the counter, but only with a doctor's permission. Adderall (mixed amphetamine salts) is a psychostimulant drug that was initially approved. modafinilly. Modafinil, sold under the brand name Provigil among others, is a central nervous system stimulant medication used to treat sleepiness due to narcolepsy, shift work sleep disorder, and obstructive sleep apnea. Provigil may also be used for other purposes not listed in this medication guide. Is Provigil a stimulant? Yes, Provigil drug class is stimulant, and Modafinil schedule is Schedule IV controlled substance according to information from the United States Drug Enforcement Agency (DEA). The proGAV is a position-dependent valve. This means that it can be optimally adapted to the. Excipients with known effect. Coverage by Medicare plans may vary or require special exceptions to be made. 0 provides effective decompression of hydrocephalic patients, significantly reduces the number of valve revisions per patient and had a significantly greater mean time to revision than fixed-pressure valves. Examples include headache and nausea. 5 years. There was a significant. unusual tiredness or weakness. 99 for the most common version, by using a GoodRx coupon. Avoid or Use Alternate Drug. The proGAV 2. If you are one of the many people wondering how to get. Modafinil is a prescription medication known as a "eugeroic" which are wakefulness promoting drugs that stimulate the central nervous system by affecting the circadian rhythm part of the brain. AccessGUDID - proGAV 2. Do not take this medicine after the expiry date which is stated on the blister and the carton after ‘EXP’. Off-label it has been used to help people with Parkinson's Disease, ADHD, chronic fatigue. As counterintuitive as it may sound, once I began to regularly exercise, my fatigue greatly improved, and these medications became so much more effective. 75, which is 97% off the average retail price of $719. dryness of the skin. For the full list of excipients, see Section 6. In 2020, it was estimated that about 850 thousand prescriptions were filled in the U. Download Practo app. It is not known how modafinil works to keep you awake. Keep Provigil in a safe place to prevent misuse and abuse. Provigil may also be used for purposes not listed in this medication guide. Cytoprotective effects may occur through increases in bicarbonate ion (HCO. Contains sugars as lactose. You should not use this medicine if you have had an allergic reaction to modafinil or other similar medicines (such as armodafinil, Nuvigil®). Mechanism of Action. 4%) compared to patients on placebo (0. uncontrolled movements of the face, mouth, or tongue. , Boston, MA 02114, or at [email protected. It belongs to a group of medications called stimulants. Do not use PROVIGIL for a condition for which it was not prescribed. Modafinil is an active ingredient used in Provigil® medicine. +৩২৫ মি. Also, baclofen. A patient with theModafinil may also induce its own metabolism. Then they stopped each medication and waited two weeks before starting the next. It is an eugeroic medication, which means it is wakefulness-promoting agent. I also have built up a tolerance to the 200mg so it has started to wear off about 4 hours after taking it and is a very hard medicine to get the dosage upped on. Storage . Modafinil (Provigil; 200 mg once daily) This medication is not a stimulant but is used to improve wakefulness in patients with excessive sleepiness. The most common events across the board. Provigil and Vyvanse (lisdexamfetamine dimesylate) are stimulants used to treat different conditions. Modafinil tablets are a prescription medicine used to improve wakefulness in adults who are very sleepy due to one of the following diagnosed sleep disorders: narcolepsy; obstructive sleep apnea (OSA). Modafinil is a medication used to improve wakefulness due to a variety of sleeping disorders. Solriamfetol (Sunosi) and pitolisant (Wakix) are newer stimulants used for narcolepsy. The proGAV is a position-dependent valve. Provigil is a medication that promotes wakefulness. Keep all medicine out of the reach of children. gb | instructions for use instructions for use , the progav progav progav ): Depression: Modafinil is an anti-sleeping medication, and it keeps one awake for long periods; lack of sleep and disruption of the normal sleep-wake cycle can lead to the triggering of the onset of mental health issues. An American Academy of Sleep Medicine clinical practice guideline. Over-the-counter. Of the total drug interactions, 71 are major, 211 are moderate, and 181 are minor. It’s most often used to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, and shift work. Avapritinib. 6 L/kg). Modafinil, sold under the brand name Provigil, increases dopamine in the brain, similar to stimulants. since 1998 to treat sleep-related conditions such as narcolepsy and sleep apnea, heightens alertness much as caffeine does. Doctors typically prescribe this medication first because it is less addictive and has fewer side effects than other stimulants. ). Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Modafinil has been shown to significantly increase dopamine in the brain by blocking dopamine transporters; however, has a lower affinity for dopamine receptors compared to amphetamines (Volkow 2009). • Keep PROVIGIL and all medicines out of the reach of children. Modafinil does not cure these conditions and will only work as long as you continue to take it. The American Academy of Sleep Medicine recommends modafinil for people with OSA who still have excessive sleepiness when using CPAP therapy. Modafinil is a controlled substance, but it is categorized at a lower level of control and severity. Provigil (modafinil) is a prescription drug used to treat excessive sleepiness. Amphetamines (e. 1 Name of Medicine. Provigil (modafinil) and Nuvigil (armodafinil) are oral prescription drugs used to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA) and shift work disorder (SWD), a sleep disorder affecting people who work overnight or nontraditional shifts. The right medication and the right dose vary among individuals, so it may take time to find out what's right for you. m. An implantable device intended to function as part of a lumboperitoneal, ventriculoperitoneal or ventriculoatrial shunt to regulate the pressure and flow level of cerebrospinal fluid (CSF) from the lumbar spine or brain to the peritoneum/heart right atrium in the management of increased intracranial pressure (e. 44-3. Solriamfetol (Sunosi) and pitolisant (Wakix) are newer stimulants used for narcolepsy. Order Modafinil online without a prescription. The latest documented valve setting of the proGAV ® group and Codman Hakim ® group was median 50 mm H 2 O and 120 mm H 2 O, respectively. The present study investigates this development by analyzing shunt- and valve-related outcomes for this. Increased monitoring of BP may be appropriate during therapy. It works by altering neurotransmitters in the brain. 0 offers the reliability of our existing technology with a new tactile “Feedback” mechanism and “Soft-Touch” instrumentation. This kind of medication has only been used to treat sleeping concerns such as sleep apnea, obstructive sleep apnea, and circadian rhythm disorders such as shift work. Since the efficacy of modafinil is consistently described and there is much experience with this substance, it is reasonable to start with modafinil as a first choice treatment. BackgroundModafinil is a novel wake-promoting agent approved by the FDA ameliorating excessive daytime sleepiness (EDS) in three disorders: narcolepsy, shift work sleep disorder and obstructive sleep apnea. Ask your doctor or pharmacist if you have any questions. Provigil can cost more than $950 out-of-pocket, but with a coupon from SingleCare, you could get a 30-day supply of the generic for less than $60. Modafinil is a medication prescribed to treat excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder. Clinical records and imaging of all patients fitted with proGAV®2. In cases of multiple sclerosis (MS), Provigil may be prescribed off-label to treat fatigue and sleepiness. The purpose of this study is to provide a single reference for the identification of programmable shunt valves and the interpretation of programmable. You should avoid alcohol while taking modafinil (Provigil), as well as. Do not start or stop taking modafinil throughout maternity without your medical professional's suggestions. While the medicine is predominantly prescribed to those living with narcolepsy or sleep apnea, some reports say drugs like Modafinil are becoming popular among students. Modafinil administration has resulted in cognitive improvement in patients with attention-deficit hyperactivity disorder, major depression, and schizophrenia and in healthy populations (), as well as decreased fatigue in patients with other medical. Modafinil has been linked to irregular heartbeats (arrhythmias) and increases in blood pressure, so you'll need to be regularly monitored during treatment to check for these problems. Differential pressure valves are a popular treatment modality, with evidence suggesting that incorporation of gravitational units helps minimise over-drainage. 800. 1. Treatment. Modafinil, available under the brand name Provigil, is a central nervous system stimulant drug. Search for termsModafinil is a prescription-only drug in most Western countries. Armodafinil and modafinil . Performance by pilots without the medication degraded by 60 to 100 percent compared to fully rested. Nuvigil and Provigil have different chemical structures. 2, 3 Several tests such as the Epworth sleepiness scale 1 were used to assess the outcomes. It was made to help treat obstructive sleep apnea and shift work sleep disorder but is used off-label to treat MS fatigue. Warnings Modafinil is a medication that promotes wakefulness. It is an effective medication approved for promoting wakefulness in individuals with sleep disorders.