011 mg/lb (24 μg/kg) moxidectin, and 2. DISCLAIMER: ALTHOUGH GREAT CARE HAS BEEN TAKEN IN THE COMPILATION OF THIS DOCUMENT, READERS ARE REQUESTED TO REFER TO THE PACKAGE INSERT FOR COMPLETE DETAILS. The Trio minimizes the risk of paralysis tick and tick infection by eliminating paralysis ticks and brown dog ticks. I gave my two dogs Simparica Trio on 5/17/22 per the vet. 2. Two field studies were. He had been taking the it for about 2-3 months. While Nexgard is a beef flavored chewable treatment, on the other hand, Simparica is a liver flavored one. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. 00, I received a $20. A study cited by the NIH attested to its 97. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Simparica Chewable Tablet for Dogs, 88. 1-22 lbs, (Orange Box), 12 Chewable Tablets (12-mos. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. As we said, these are the same class of neurotoxin, but there are some slight differences. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. Starting 9/1/2023, WalmartPetRx. Simparica Trio Chewable Tablets for Dogs is a monthly oral medication that helps protect against fleas, ticks, heartworms, and other intestinal parasites in dogs. In both studies, Simparica TRIO® was 100% effective at killing I. The green box Simparica Chewable Tablets for Dogs, 44. Então comprei um original para comparar. 8 pounds or more. Simparica was found to be more effective than NexGard at killing five different types of ticks within the first 24 hours. 8 pounds or greater. These ingredients target parasites differently, and understanding their mechanisms can guide your choice. 27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Nexgard : Boehringer Ingelheim. Simparica Trio for Dogs. Save £21. 27 per dose. Determined to develop superior protection, Simparica created a treatment that can protect your pets from fleas and ticks all month long—without losing its effectiveness at the end of the month. This leads to uncontrollable neuromuscular. Amblyomma cajennense or the Cayenne tick is a three-host ixodid tick species of low host specificity during its immature stages. 4. 00 for a three month supply (3 pills). 0 lbs should be. 2 mg/kg)Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. For 1 tab, effects lasts for 1 whole month. scapularis ticks. 91 for 3 doses or $95. A veterinarian would provide the most adequate information to cater for your dog’s well-being. Simparica is a trusted oral medication for dogs that provides adequate monthly protection against fleas and ticks. Urban areas with dense pet populations can also propagate the spread of fleas and ticks. 61 per dose. 1-88 lbs is $98. †Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria. Pack Contents: 3 Chewable TabletsDosage & AdministrationFor oral use. No. Credelio is an excellent flea and tick treatment for dogs and puppies over 8 weeks of age and weighing more than 4. 8 lbs / 1. Advantus (Imidacloprid) Chewable Flea Treatment for Small Dogs, 7 Count, 4-22 Pounds. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. . Active Ingredient. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Simparica Trio boasts a broader spectrum of protection, offering defense against both external and internal parasites. This medication contains a powerful Sarolaner, a powerful isoxasoline drug, which the FDA warns can produce serious. 53 with Subscribe & Save discount. 9%) voluntarily consumed by free choice without, or when offered in food. By clicking 'Accept' you confirm that this describes you. Simparica Trio might be more expensive when the two are side by side, but ultimately it is the better value. Zoetis UK Limited. supply) at Chewy. When a parasite like a flea or tick bites your dog, they ingest the sarolaner along with their “meal,” which disrupts their nerve cell functions and kills them. Approved for use in dogs over the age of 8 weeks and above 2. The most frequently reported adverse reactions were vomiting and diarrhea. It contains sarolaner, which kills fleas and ticks,. Q. Last updated November 21, 2023. Starting 12/31/2023, WalmartPetRx. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. Compare Simparica vs. 91 mg/lb) body weight. SIMPARICA should not be used in dogs less than 6 months of age (see Animal Safety). 6% reduction in adult fleas within 14 days after treatment and reached 100% on Day 60. Each tablet is formulated to provide minimum dosages of 1. Simparica Trio should be given orally once a month at the recommended minimum doses: 0. Simparica is slightly cheaper than Comfortis and is also effective against mites and ticks. Dog owners may notice a marked reduction in their pet’s energy levels, less enthusiasm for walks or play, and more time spent sleeping or resting. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Off-label, it is used to manage ear mite infestations, sarcoptic and demodectic mange. By 5/30, he needed diapers. Buy Simparica flavored chewable flea and tick preventative for dogs at discounted rates. Simparica is the only monthly tick and flea chewable for dogs approved to kill 5 types of ticks: Gulf Coast tick, Brown dog tick, Deer tick/black. 2. The meaning of SIMPER is to smile in a silly, affected, or ingratiating manner. 10%. Many traditional (and even some holistic) veterinarians are strongly recommending the use of the isoxazoline class of pSimparica Trio is a powerful, chewable medication designed to protect your four-legged friends from heartworm disease, ticks, fleas, and several internal parasites. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. How to use simper in a sentence. The box has the following precaution: Sarolaner, one of the ingredients in Simparica Trio, is a member of the isoxazoline class. While Simparica Trio is generally safe, some dogs may. You can use Simparica Flea and Tick Medication monthly to keep your dogs safe from these pesky parasites. Simparica is developed and designed. 91 mg/lb (2 mg/kg). . Both products effectively kill adult fleas within just a short time after being given and last for a month. 1-88. Dogs weighing between 5. 8 to 5. Each tablet is formulated to provide minimum dosages of 0. Simparica is a flea tick chewable tablet from Zoetis USA whose primary ingredient is Sarolaner. The brown box Simparica Chewable Tablets for Dogs, 88. However, it cannot be used in pets under 6 months of age. Simparica is given orally once a month at the recommended minimum dosage of 0. NexGard tablets kill fleas within 4 hours and ticks in about 24 hours. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. This includes all three doses of the medication, which are given at 2-week intervals. Each tablet is formulated to provide a minimum sarolaner dosage of 2 mg/kg (0. $1990 ($0. Unsure which flea & tick medication to choose for your pup? Check out our comparison of Simparica Trio vs. Simparica Trio does the work of two or three parasiticides in a single chewable by combining three proven ingredients. Type: Over-the-counter, topical | Active ingredients: Imidacloprid, permethrin, and pyriproxyfen. Simparica is a once-monthly, safe, and effective chewable flea and tick preventative for use in dogs. You may purchase prescriptions and refills from the pharmacy of your choice. You can ask your vet for a single dose to see if your dog will. ago. 91 mg/lb (2 mg/kg) sarolaner. Nexgard is useful for when you can’t get Simparica, but we love the faster, more thorough. Tablet strength 6 mg/0. Had to take him to the vet over the weekend for intractable diarrhea when progressed to vomiting, anorexia and understandably lethargy after simparica trio. Simparica 10 mg chewable tablets for dogs >2. Simparica Trio kills Gulf Coast, Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Service. 1-88 lbs. The chews also help in eliminating fleas and ticks including five tick types: Black-legged ‘deer’ ticks, American dog ticks, Gulf Coast ticks,. Trifexis contains two active ingredients - Spinosad and Milbemycin Oxime. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. Most dogs readily take this chewable tablet. 8 pounds or greater. 8 to 5. Compared to other products, the efficiency of this. Geometric mean worm counts for the placebo groups in Studies 1 and 2 were 21. Simparica Acts Fast Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. 72. This monthly chewable Simparica Trio is 100% protection and the advanced product among all. Simparica Trio is a widely used flea and tick preventative medication for dogs. Geometric mean worm counts for the placebo groups in Studies 3 and 4 were 209. 4,200. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Our Review of Simparica and Comfortis. The dosage depends on the dog weight and age. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Simparica 44. Tennessee Tax Rebate 2023 – The Tennessee Tax Rebate 2023 aims to provide financial relief to eligible taxpayers in the state. This comprehensive guide will. Simparica is provides effective flea and tick protection for one full month. Simparica Trio is an FDA-approved, chewable tablet formulated to prevent heartworm disease, kill ticks and fleas, treat and control roundworms and hookworms in dogs. Tablets can be administered with or without food. Sarolaner restricts the function of the nerves at the neuromuscular junction in parasites. diseases caused because of them. 50 and $1. . SIMPARICA TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. 1 Unlike others on the market,. 5, with an efficacy of 4. Simparica is a tasty chewable flea treatment that goes down a treat protecting your dog against fleas, ticks, mites and sarcoptic mange from 8 weeks of age. Sarolaner is also used in combination products for both dogs and cats. $49. Once administered, Simparica chewable for dogs starts killing fleas within 3 hours of. Simerics-MP CFD for Autodesk® Fusion 360®. Simparica (sarolaner) “The active substance of SIMPARICA, sarolaner, is an acaricide and insecticide belonging to the isoxazoline group. There are four sizes to choose from based on your pet’s weight. pulci. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. They know there's no time to waste when it comes to protecting our furry friends, so Simparica starts killing fleas and ticks within hours and keeps. This product is safe for use in pregnant or breeding dogs. Simparica 80 mg chewable tablets for dogs >20–40 kg. Simparica offers a hamburger-size portion as well as parts of chicken. Nexgard starts killing fleas in 4 hours and ticks in 48 hours. Simparica Trio for Dogs. 5–5 kg. 1. 8-5. 0 lbs should be given one 10 mg Simparica chewable tablet monthly. Both Bravecto and Simparica offer effective and fast-acting prevention against fleas and ticks. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Range. Simparica has been safely used. 1-10 kg. Para fazer efeito, a dose deve ser dada de acordo com o peso do animal. 27 mg/lb (5 mg/kg) pyrantel (as. Rating DistributionSIMPARICA ® (sarolaner) is a flavoured chewable tablet containing 5, 10, 20, 40, 80, or 120 mg of sarolaner, an ectoparasiticide intended for administration to dogs according to their weight. The real issue is. 5. 1 Simparica Trio is an FDA-approved prescription medication that can help to prevent a number of infections caused by parasites, including those of which can lead to Lyme disease, caused by deer ticks. More than 98% efficacy in killing existing tick infestations in 48 hours. It is indicated for the effective control of fleas and ticks. Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2. 2. Simparica is the highly palatable new treatment for fleas, ticks and mites for dogs from eight weeks of age. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrhea—both symptoms related to Fido’s digestive tract, rather than his nervous system. Simparica Trio is a popular flea and tick preventative medication for dogs. Simparica kills adult fleas, and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations from lonenstar ticks, Gulf Coast ticks, American dog tick, black-legged ticks and brown dog ticks for one month in dogs 6 months of age or older and weighing at least 2. Simparica works by entering your dog’s bloodstream and due to the nature of its active ingredient ‘Sarolaner’, it becomes an ectoparasiticide to effectively kill any parasite. 2. Consistency is key to maintaining a flea and tick-free environment. Buy Simparica Trio Chewable Tablets for Dogs recommended for use in dogs and puppies 8 weeks of age and older. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against: *Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus. Simparica Trio Chewable Tablets for Dogs are indicated for the treatment of dogs with, or at risk. 0 mg/0. Buy Simparica Chewable Tablet for Dogs, 44. It is also used for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections. Get Simparica Trio for as low as $180. Simparica 5 mg chewable tablets for dogs 1. 1-88 lbs, (Green Box), 3 Chewable Tablets (3-mos. 6 and 11 pounds 1. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. 00 for 3 doses or $99. Isoxazoline based products used for prevention and treatment of fleas, ticks, and mites (Bravecto, Bravecto Plus, Nexgard, Simparica, Simparica Trio, Credelio, Revolution Plus) are gaining popularity. 1 to 132 pounds, along with three options for the number of chewables to purchase at one time: three, six, or twelve. Nexgard is given every four weeks. Como é o comprimido do Simparic? Simparic é um comprimido mastigável altamente palatável, à base de. Side Effects. He improved with antiemetics and SC fluids, it was pretty upsetting to see him experience these side effects though. Your credit card statement will reflect a charge by Vetsource for your purchase. Simparica® Chewable Tablets for Dogs 20mg (5kg-10kg) SRP £36. Simparica Trio Chewable Tablets for Dogs. The active ingredients in Simparica Trio are sarolaner, moxidectin, and pyrantel. : G4321 (Act 36/1947). Description. Dogs get all this protection with just one dose of Simparica Trio. ConclusionsSimparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. The main goal. Given a chewable texture and a palatable flavour for ease of administration, Simparica works by acting on the parasites nervous system, inducing paralysis and. Simparica Trio and Nexgard are highly effective against fleas and ticks. It can also prevent new infestations of. 3–2. 048 mg/kg moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table. It has a quick-acting, long-lasting formula that starts working within hours of application and keeps working for a full 35 days. Simparica Trio® is intended for. 048 mg/kg of moxidectin and 5–10 mg/kg of pyrantel in accordance with the following table: Bodyweight (kg) Tablet strength 3 mg/0. Simparica Trio is a monthly chewable tablet for dogs that provides comprehensive protection against fleas, ticks, heartworms, and intestinal worms. Coupon Codes 5. . FREE delivery Wed, Nov 29 on $35 of items shipped by Amazon. 99 - $120. Compared with the other isoxazoline tablets ( NEXGARD with afoxolaner , BRAVECTO with fluralaner ), SIMPARICA controls not only ticks and fleas, but also mange mites ( Sarcoptes scabiei) after two consecutive monthly treatments. SIMPARICA should not be used in dogs less than 6 months of age (see Animal Safety). It's a flavored, chewable tablet used by or on the order of a licensed veterinarian to: Prevent Borrelia burgdorferi infections caused by the killing of Ixodes scapularis vector ticks. 00 for an approved alternative tick treatment for dogs, or reimburse you the cost of one dose ofSimparica should be administered orally to your dog, once every month, at the minimum dosage of 0. 5 kg. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Simparica chewable tablets for dogs. 6 to 11 pounds. Simparica Trio also prevents heartworms and keeps hookworms and roundworms from. Simparica chewable tablets contain sarolaner as active substance, an ectoparasiticide belonging to the isoxazoline group, which is active against ticks, mites and fle as. Remember, Simparica Trio prevents heartworm disease but is not effective against adult D. 99 Chewy Price. Simparica Trio is a once-monthly chewable tablet that can treat existing flea and tick infestations and help prevent fleas, ticks, heartworm, roundworm and hookworm. A study cited by the NIH attested to its 97. Dogs weighing 5. Get 20% off your first Chewy Pharmacy order with code GOODRX20. Heartworm Prevention SIMPARICA TRIO should be administered at. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. 69. 3. $2898 ($4. It's a tasty tablet that works to shield your pet for a full 35 days, killing fleas before they can lay eggs. 25% Off Order Over $99 with Simparica Amazon Promotional Code. S. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2. Each tablet is formulated to provide minimum dosages of 1. Can dogs have a reaction to Simparica Trio? In a third field safety and effectiveness study, SIMPARICA TRIO was administered to 120 dogs with roundworms. Save $30. It is notably a medication for protection from Gulf coast. Currently, for Simparica, less than 0. See full Prescribing Information. It is indicated for the treatment and prevention of flea infestations. Simparica Trio is a relatively new product on the market, so the pricing may vary depending on where you purchase it. A novel chewable oral tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) has recently been developed to provide persistent protection against flea and tick infections for a month, treatment of hookworm and roundworm infections and prevention of heartworm and lungworm disease in dogs. Simparica Trio for dogs is a chewable tablet that enhances your dog’s protection against parasites. (Originally $63. 8 lbs, please note that depending on the pest. Description. Simparica Trio Chewable Tablets for Dogs 44. 5 out 5 in ratings from a vet’s viewpoint. Simparica Trio can be administered to puppies over 2. Simparica works by entering your dog’s bloodstream and due to the nature of its active ingredient ‘Sarolaner’, it becomes an ectoparasiticide to effectively kill any parasite. For many, Simparica Trio, a comprehensive flea, tick, and heartworm preventative, has been a game-changer. 5, and ease of use a 4. rogna demodettica e sarcoptica. Product Description. Simparica Trio costs $135 to $150 depending on your dog's weight. It offers protection from heartworm disease, kills fleas before they can lay eggs, treats and prevents flea infestations, kills 5 different types of tick, and treats and controls roundworms and hookworms. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. 61 per dose. Simparica Chews (Green) for the treatment and control of fleas and ticks is safe and effective to be used in dogs form 6 months of age and weighing between 44. ; It can eliminate as many as five tick species: gulf coast. A20: While Simparica Trio has been associated with adverse neurological reactions, including seizures, in rare cases, it is generally considered safe for use in dogs without a history of neurological issues. It contains three active ingredients: sarolaner, moxidectin, and pyrantel, with sarolaner being potentially. The FDA considers this level to be “very rare”. Simparica is given orally once a month at the recommended minimum dosage of 0. Simparica Trio contains three active ingredients. Each package includes six doses. My 2 year old Golden started having focal seizures as a result of this medication. One study shows that this medication is 96. Drug Information. 4. A 6-month supply of chewable Simparica tablets ranges in price from $80 to $100 on average. Simparica 88-132 dogs. 45 - $282. Shipping calculated at checkout. Some limitations and restrictions may apply. 877-738-4443. Środek przeciwpasożytniczy ma słabo wyrażoną zdolność do kumulacji w organizmie, dlatego jego działanie utrzymuje się przez długi czas - do 35 dni. The most frequently reported adverse. The aim of this study was to determine the clinical safety of Simparica Trio ® (sarolaner, pyrantel, moxidectin) in heartworm-infected dogs and the degree of microfilaricidal and adulticidal activity of three consecutive monthly treatments of Simparica Trio. Simparica Trio kills Gulf Coast, Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. 12 mg/25 mg. 8 pounds. 1-20 kg. 1-88 lbs is $98. Como tratar intoxicação de ivermectina em gatos? O tratamento das intoxicações causadas pela ivermectina requer suporte e fluidoterapia intensa com cristalóides. 8 pounds or more. 54 mg/lb (1. The most frequently reported adverse reactions were vomiting and diarrhea. 1-88 lbs 88. Webinar Series 2023. 91 mg/lb) body weight. It can also prevent new infestations of these pests. Simparica Trio contains a specially optimised trio of ingredients for proven efficacy including the ingredient moxidectin, the same ingredient used by vets to protect against deadly heartworm disease. 1-88 lbs, (Green Box), 6 Chewable Tablets (6-mos. Simparica Trio treats and protects against harmful parasites. 01% of dogs taking this medication have experienced any neurologic side effects. Simparica Trio from Zoetis Petcare provides flea, tick and heartworm prevention for dogs, plus targeted intestinal parasite control that lasts for an entire month. 6 and 11 pounds 1. 6 to 11. It can treat 5 parasites at a time and can protect well against heartworm disease, ticks & fleas, roundworms even hookworms. Buy Simparica Trio Chewable Tablet for Dogs, 44. at. This article delves into the specifics of Simparica Trio,. 2 mg/kg sarolaner, 24 µg/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). Closure of Site. It begins killing fleas within 3 hours and ticks within 8, and it maintains efficacy until the next monthly dose. $76 for 6. When Itching Becomes a Concern. Dogs weighing between 2. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. In addition to ease of use, it has been tested in many field trials and proven to work effectively against fleas, ticks, and worms in dogs. It’s the newer tablet-based Isoxazoline products that are the real game changers. However, as with any medication, it's important to understand the potential side effects and how long they might last. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star. 4 star rating based on 14 customer reviews and ranks 179 of 560 among companies in Pet Stores category. Gave my dog her monthly dose of Simparica (this is her 6th time taking it, no issues the other 5 months). Simparica. Simparica Trio Results Value: Simparica Trio Both preventatives are have six weight brackets to choose from: 2. It is the most convenient flea and tick protection product on the market. Nesse vídeo eu falo sobre os comprimidos mastigáveis Bravecto, Simparic e Nexgardz digo se eles realmente acabam com pulgas e carrapatos em cachorros, coment. Heartgard, on the other hand, is a veteran in the field, predominantly known for its effectiveness against. Simparica maybe be used as an alternative to the product NexGard. The most frequently reported adverse. Buy Simparica Chewable Tablet for Dogs, 22. Both products are also safe for use in puppies. Tablets can be administered with or without food. Datasheet & Company Info. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. 024-0. 6-11 lbs 11. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. Is Simparica Safe for Dogs? Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. com will shut down permanently. 27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). If this occurs, notify your veterinarian. In laboratory safety studies, no interactions were observed when sarolaner was co-administered with milbemycin oxime, moxidectin and pyrantel pamoate.